In November 2014, Caltrans District 7 installed two signs designating a segment of U.S. Highway 101 as part of the National Purple Heart Trail — a system of signed highways, bridges and other monuments that honor soldiers who have received the Purple Heart medal.

One of these signs can be seen on the northbound 101 in Thousand Oaks, right before the Westlake Boulevard offramp. The other sign is near the Bates Road offramp of the southbound 101.

These two signs complete 240 continuous miles of Purple Heart trail in California, from Ventura County to Monterey.

Senate Concurrent Resolution No. 27 established specified portions of US Highway 101 in the counties of Santa Barbara and Ventura for inclusion in the National Purple Heart Trail.

The U.S. 101 in Ventura County is also dedicated to the U.S. Army's 101st Airborne Division as commemorated by "The Screaming Eagles Hwy - 101st Airborne Division" placed nearby.